Audacity is the tool everyone should start with to learn: http://web.audacityteam.org/. It not only receives input from your sound card but also audio interfaces such as http://www.sweetwater.com/store/detail/US16x08 which can send 8 signals/channels, not just 2. So you can mix 8 channels down to stereo. It is the recommended tool for PODs or audio blogs.
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